Prof. RNDr. Blanka Říhová, DrSc.
Project of Prof. RNDr. Blanka Říhová, DrSc. from the Institute of Microbiology of the Czech Academy of Sciences brought hopeful results in the field of tumour cells and cytostatic agents. The current advancement in chemotherapy is mainly aimed at the development of new types of cytostatic agents with lower toxicity which inhibit the creation of resistance. The resistance to particular cytostatic agent and multidrug resistance (MDR) is a frequent reason for the failure of chemotherapy. The project team brought new findings proving that the systems for medicaments transfer based on HPMA copolymer conjugates carrying cytostatic agents and P-gp inhibitors are capable to effectively overcome gained and natural multidrug resistance. The results were published in series of scientific journals in the Czech Republic and abroad.